Inactive X is supposed to be methylated right?
Inactive X is supposed to be methylated right?
It is generally thought that the inactive X chromosome (Xi) in female cells is silenced through methylation of CpG islands. This paper demonstrates that on a global level the Xi is actually hypomethylated and the active X is hypermethylated. I haven't made it all the way through the paper, but it seemed controversial enough to post now.
Submitted by Geoff on Thu, 02/22/2007 - 6:19pm. | Tags: Journal Article | Life Science
Is this like cancer?
It looks like the data in this paper about the X chromosomes are similar to what is observed in cancer cells. Hypermethylation at specific promoters combined with global hypomethylation. Very interesting.